The problem of formation plugging exists in Lower Member reservoir of S2 and Upper Member reservoir of S3 in Shangsan Region of Shanghe Oilfield during the process of developing. Through testing water samples quality and analyzing formation compatibility of water samples by experiments, this paper looks for the damage caused by plugging and conducts plugging experiments. By analyzing particle size, ion content and scaling tendency of the injected water, it is found that the particles plugging and scaling phenomenon exist in injected water. Then driving injected water to block core, water-sensitive phenomenon appears. Aimed at the damage type, acidification and reduced swelling experiments are done. The core permeability of Lower Member reservoir of S2 greatly improves after injecting the system of 12% hydrochloric acid+multi-hydrogen acid+mud acid.