After years of technology development, horizontal wells have be applied in different kinds of oilfield at home and abroad and shown obvious superiority. But for the stratified reservoir with multi-layer sandstone such as S oilfield were concerned, the application effect of horizontal wells and directional wells need further research and analysis. Based on S oilfield, the strengths and weakness of horizontal wells and directional wells were firstly evaluated by analyzing production data. And the research target and direction were put forward. Then based on actual reservoir numerical simulation model, it was concluded that for the reservoir similar to S, the single control reserves would greatly influence the production effect of horizontal wells and directional wells using digital virtual development technology. At last, the application effect of horizontal wells and directional wells were also related to various reserves figured out by establishing the theoretical numerical model. In general, the development effect of directional well was better than that of horizontal well in stratified reservoir with multi-layer sandstone. The study result provided the support and reference for the selection of well type in the process of secondary development of oilfield.