Strata developed well in Cenozoic and Mesozoic of Tarim Basin and buried depth is within 5,000 m with thick formation. But diagenesis period is late. Compaction degree is low and formation drillability is relatively good, which is the focal section of hydraulic breaking rock. The high-strength drill pipe with non-standard water hole is studied, which can decrease the hydraulic consumption. Bit hydraulic horsepower and injection power are improved at same pump pressure, which hydraulic breaking rock effect is improved. A good effect has been obtained through field application. Drilling cycle is shortened for 20.54 days compared with the designed days and the shortened rate of cycle is 38.76%. ROP raises 2.63 m/h and rising rate is 43.62%. Drilling with high quality and high speed is realized in upper section of ultra-deep well.