4-氯-1, 2-二甲基苯的高选择氯代合成新方法

A Novel Synthetic Method of 4-Chloro-1,2-Bimethyl-Benzene by High Selective Chlorination Reaction

钱建华 张庆春 刘 琳 邢锦娟 龚树华

QIAN Jian-hua ZHANG Qing-chun LIU Lin XING Jin-juan GONG Shu-hua

         (渤海大学应用化学重点实验室, 辽宁锦州1 2 1 0 0 0

  Provincial Key Laboratory for Applied Chemistry, Bohai University，Jinzhou Liaoning 121000,P.R.China

关键词: 路易斯酸, 选择性, 对位氯化

The selective chlorination reaction of the aromatic ring among the aromatic compounds is very important in the economy and environmental protection aspects. A novel chlorination reaction system HCl-H2O 2-CH3COOH was applied to react with o-xylene. Compared to the traditional Lewis acid catalysts which comprised sulfur and zeolite catalytic chlorination system, it took on much superiority such as high-selectivity, high-yield, simple operation, savings and environmental protection etc. The reaction conditions were controlled, the molar ratios of hydrogen peroxide, hydrochloric acid to o-xylene were 5.0,4.0 respectively, the reaction was processing under 70 ℃ until the feeding was finished and then the reaction was 2 h under 90 ℃. The conversion ratio of the raw material is over 99%, the yield is 96.9% and the selectivity is over 99% under this condition.

辽宁省优秀人才支持计划项目( R C-0 5-0 9) 。