2-取代-2,3-二氢-4(1H)-喹唑啉酮衍生物合成方法

Sy nthetic Method for 2 -Subs ti tuted -2 , 3 -Dihydro -#br# 4(1H)-Quinazolinones Derivatives

1.渤海大学化学化工与食品安全学院,2.中国石油四川石化有限责任公司生产一部

1. College of Chemistry, Chemical Engineering and Food Safety, Bohai University, Jinzhou Liaoning 121000, P.R.China; 2. The First Produce Department of PetroChina Sichuan Petrochemical Co., Ltd., Chengdu Sichuan 611930, P.R.China

关键词: 2, 3 -二氢-4(1H)-喹唑啉酮 , 氯化铝 , 2 -氨基苯甲酰胺 , 醛 , 酮

A series of 2-substituted-2,3-dihydro-4(1H)-quinazolinones derivatives were synthesized efficiently by the cyclocondensation of 2-anthranilamide with an aldehyde or ketone in the presence of aluminum chloride in water at 60 ℃ after grinding at room temperature. The catalytic activity of different catalysts was compared. The effects of the amount of catalyst and the amount of solvent on the yields were investigated. The results show that the best reaction results could be obtained when the molar ratio of 2-anthranilamide to an aldehyde or ketone is 1∶1, the amount of catalyst is 1% (based on the mole of reactant), and water is 2 mL. The structures of products were characterized by IR, 1H-NMR, mass spectrum and elemental analysis. The probable catalytic mechanism for the reaction was proposed.

辽宁省博士科研启动基金资助项目(2009A033)

10.3696/j.issn.1006-396X.2011.03.004