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铜催化的一种长烷基支链脂肪醇的合成

辽宁石油化工大学学报

2021年 41卷第No.4期

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Title

Copper⁃Catalyzed Synthesis of a Long Alkyl Branched Fatty Alcohol

作者

刘宇珂闫飞孙京周明东

Authors

Yuke Liu Fei Yan Jing Sun Mingdong Zhou

单位

辽宁石油化工大学石油化工学院，辽宁抚顺 113001 辽宁省产品质量监督检验院，辽宁沈阳 110032

Organization

School of Petrochemical Engineering，Liaoning Petrochemical University，Fushun Liaoning 113001，China Liaoning Provincial Supervision and Test Institute for Products Quality，Shenyang Liaoning 110032，China

摘要

研究了过渡金属铜催化的对甲基苯磺酸酯类化合物与烷基格氏试剂的交叉偶联反应，可以简单高效地制备一种长烷基支链的脂肪醇。在最佳反应条件下，能够以65%的分离收率获得10?辛基二十烷醇。进一步通过核磁共振（NMR）手段对其进行表征，确认了化合物的结构。

Abstract

An transition metal copper?catalyzed cross?coupling reaction of tosylates with p?toluene sulfonate compounds and alkyl Grignard reagent has been developed, and a long alkyl branched fatty alcoholto could be synthesized simply and efficiently. 10?octylicosan?1?ol was obtained in 65% isolated yield under the optimized reaction conditions. It was further characterized by nuclear magnetic resonance,the structure of the compound was confirmed.

关键词：

铜催化; 假卤化物; 格氏试剂; 交叉偶联;

Keywords:

Copper catalysis; Pseudo?halides; Grignard reagent; Cross?coupling;

基金项目

辽宁省教育厅基本科研项目(L2016022)

DOI

10.3969/j.issn.1672-6952.2021.04.003