2⁃乙基⁃2⁃芳基⁃二氢喹啉衍生物的合成

Synthesis of 2⁃Ethyl⁃2⁃Aryl⁃Dihydroquinoline Derivatives

朱超凡 王锐 陈运荣

Chaofan Zhu Rui Wang Yunrong Chen

辽宁石油化工大学 石油化工学院，辽宁 抚顺 113001 上海科技大学 物质科学与技术学院，上海 201210

School of Petrochemical Engineering，Liaoning Petrochemical University，Fushun Liaoning 113001，China School of Physical Science and Technology，ShanghaiTech University，Shanghai 201210，China

研究了2?乙基?2?芳基?二氢喹啉衍生物的合成方法。合成分成三步：第一步，2?溴喹啉与苯硼酸进行Suzuki交叉偶联；第二步，进行卤锂交换；第三步，有机锂试剂在2?苯基喹啉的α位进行亲核加成，得到双取代二氢喹啉衍生物。通过此方法合成了具有二氢喹啉结构的药物，并通过各种表征手段对目标产物进行了分析，确认了目标产物的结构。

The synthesis method of 2?ethyl?2?aryl?dihydroquinoline derivatives was studied. The synthesis is divided into three steps: the first step, the Suzuki cross?coupling of 2?bromoquinoline and phenylboronic acid; the second step, the exchange of halide lithium; the third step, the nucleophilic addition of the organolithium reagent to the α?position of 2?phenylquinoline to obtain a double?substituted dihydroquinoline derivative. The drug with dihydroquinoline structure was synthesized by this method, and the target product was analyzed by various characterization methods, and the structure of the target product was confirmed.

国家自然科学基金项目(21901162)

10.3969/j.issn.1672-6952.2022.05.003