Salen金属配合物水解动力学拆分环氧氯丙烷研究进展

Research Progress of Hydrolytic Kinetic Resolution of Epichlorohydrin Catalyzed by Salen Metal Complexes

刘娜 梁光敏 季久玉 周坤 罗根祥 李微

Na Liu Guangmin Liang Jiuyu Ji Kun Zhou Genxiang Luo Wei Li

辽宁石油化工大学 石油化工学院, 辽宁 抚顺 113001 辽宁石油化工大学 人工智能与软件学院, 辽宁 抚顺 113001 黔南民族师范学院 化学化工学院, 贵州 都匀 558001

School of Petrochemical Engineering，Liaoning Petrochemical University，Fushun Liaoning 113001，China School of Artificial Intelligence and Software，Liaoning Petrochemical University，Fushun Liaoning 113001，China School of Chemistry and Chemical Engineering，Qiannan Noraml University for Nationalites，Duyun Guizhou 558001，China

环氧氯丙烷通过水解动力学拆分可得到手性环氧氯丙烷。手性环氧氯丙烷是具有很高价值的中间体，被广泛应用于医药、材料等领域。Salen是指两个相同的醛分子和一个二胺分子缩合生成的碱，其与金属化合形成的配合物被称为Salen金属配合物，常用于手性环氧氯丙烷的合成。综述了近年来Salen金属配合物催化剂的发展历程及其用于手性环氧氯丙烷合成的研究进展，探究了水解动力学拆分过程中催化剂的失活机理，对以Salen金属配合物为催化剂合成的手性环氧氯丙烷的应用进行了展望。

Chiral epichlorohydrin is obtained by kinetic resolution of racemic epichlorohydrin through hydrolysis. Chiral epichlorohydrin is a valuable intermediate which is widely used in the synthesis of medicine and material. Salen refers to a base formed by the condensation of two identical aldehyde molecules and a diamine molecule, and the complex formed by its combination with metals is called Salen metal complex, which is often used in the synthesis of chiral epichlorohydrin. In this paper, the development of Salen metal complex catalysts and their application in chiral epichlorohydrin synthesis are reviewed. At the same time, the deactivation mechanism of catalyst in the process of hydrolytic kinetic resolution was investigated and the application prospect of synthesis of chiral epichlorohydrin using Salen metal complex catalysts was prospected.

辽宁省教育厅面上项目(LJKZ0397);贵州省普通高等学校磷石膏综合利用工程研究中心资助项目(黔教合KY字[2018]010)

10.12422/j.issn.1006-396X.2023.04.008