多孔生物弹性材料的渗流数值模拟

Numerical Simulation of Seepage Flow in Porous Bioelastic Materials

陈妙超 杨盛 郭凯旋 冯金宝 玉姣

Miaochao CHEN Sheng YANG Kaixuan GUO Jinbao FENG Jiao YU

辽宁石油化工大学 辽宁省新型微纳米功能材料研究重点实验室，辽宁 抚顺 113001

Liaoning Provincial Key Laboratory of Novel Micro?Nano Functional Materials，Liaoning Petrochemical University，Fushun Liaoning 113001，China

模拟了一种多孔生物弹性体材料—聚癸二酸甘油酯（PGS)被植入人体软组织的传质扩散渗流现象；用N2吸附?脱附法表征了PGS材料的孔隙结构；用多物理场仿真软件COMSOL设计不同孔道数目和孔径的支架模型，探究了孔隙度不变时孔道和孔径参数对血液渗流的影响；用COMSOL设计适配的PGS支架模型，结合流体动力学理论，对血液流过PGS支架时的血流特性进行数值模拟，对血流场的动力黏度和剪切速率进行了分析；对不同血液入口速度下的渗流压力和扩散情况进行了对比分析。结果表明，PGS为一种趋于介孔的材料；当血液在多孔支架内流动时，动力黏度随剪切速率的变化而变化，说明血液在支架内的渗流是一种非牛顿流体渗流；在不同入口速度下，血液在多孔支架内的扩散速度不同，入口速度越大，压力越大，传质扩散速度越快。

The Biological seepage studies the seepage of biofluids in living organisms and fluids containing microorganisms in non?biological porous media.The mass transfer diffusion osmosis phenomenon of a porous bioelastomer material,poly(glycidyl sebacate) (PGS),implanted into human soft tissues was simulated.The pore structure of the PGS material was characterised by N2 adsorption?desorption and the scaffold model with different pore numbers and pore diameters was designed using the multi?physics field simulation software?COMSOL to investigate the effects of pore and pore diameter parameters on blood osmosis when the pore size was constant.COMSOL was used to design the adapted PGS stent models,numerically simulate the characteristics of the blood flow when blood flowed through the PGS stent,and analyse the kinetic viscosity and the shear rate of the blood field with the theory of fluid dynamics.Comparative analyses of seepage pressure and diffusion at different blood inlet velocities were carried out. The results show that the PGS material is a material that tends to be mesoporous.When the blood flows inside the porous scaffold, the kinetic viscosity varies with the shear rate,indicating that the blood seepage inside the scaffold is a kind of non?Newtonian fluid seepage.The diffusion speed of the blood inside the porous scaffold is different under different inlet velocities and the larger the inlet velocity is,the higher the pressure,and the faster the mass transfer diffusion speed will be.

国家自然科学基金资助项目(12074160)

10.12422/j.issn.1006-396X.2024.02.010