可见光促进的炔酸酯合成3⁃磺酰香豆素衍生物

Visible Light Promoted Synthesis of 3⁃Sulphonyl Coumarins from Alkyoates

王一越 孙语谦 陈宝宽 孙京

Yiyue WANG Yuqian SUN Baokuan CHEN Jing SUN

辽宁石油化工大学 石油化工学院，辽宁 抚顺 113001

School of Petrochemical Engineering，Liaoning Petrochemical University，Fushun Liaoning 113001，China

香豆素类衍生物是一类重要的有机杂环化合物，具有良好的生物活性。通过可见光促进的苯丙炔酸酯与苯亚磺酸钠的反应制备了3?磺酰香豆素衍生物，并研究了其反应机理。结果表明，在温和的反应条件下，以苯亚磺酸钠为磺酰自由基前驱体、过硫酸盐为氧化剂，通过串联自由基加成环化策略，可以中等到良好的产率制得3?磺酰香豆素衍生物，为功能化香豆素衍生物的制备提供了一条简洁、绿色和高效的合成路线。

Coumarins are a key class of heterocyclic lactone compounds, which have good biological activity. 3?sulfonyl coumarin derivatives were prepared by visible light promoted reaction of benzoalkynyl esters with sodium benzenesulfonate, and their reaction mechanism was studied. The results showed that under mild reaction conditions, 3?sulfonyl coumarin derivatives can be synthesized with moderate to good yields using sodium benzenesulfite as the precursor of sulfonyl radicals and persulfate as the oxidant through a cascade radical addition cyclization strategy, providing a concise, green, and efficient synthetic route for the preparation of functionalized coumarin derivatives.

辽宁省教育厅科学技术研究项目（面上项目）(JYTMS20231453)

10.12422/j.issn.1672-6952.2024.06.002